COMPUTATIONAL TOOLS FOR RATIONAL PROTEIN ENGINEERING OF ALDOLASES
نویسندگان
چکیده
منابع مشابه
Computational tools for rational protein engineering of aldolases
In this mini-review we describe the different strategies for rational protein engineering and summarize the computational tools available. Computational tools can either be used to design focused libraries, to predict sequence-function relationships or for structure-based molecular modelling. This also includes de novo design of enzymes. Examples for protein engineering of aldolases and transal...
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Aldolases are seen as an attractive route to the production of biologically important compounds due to their ability to form carbon-carbon bonds. However, for many industrial reactions there are no naturally occurring enzymes, and so many different engineering approaches have been used to address this problem. Engineering methods have been used to alter the stability, substrate specificity and ...
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ژورنال
عنوان ژورنال: Computational and Structural Biotechnology Journal
سال: 2012
ISSN: 2001-0370
DOI: 10.5936/csbj.201209016